In order to observe and quantify long-range neuronal connections in intact mouse brain by light microscopy, it is first necessary to clear the brain, thus suppressing refractive-index variations.Here we describe a method that clears the brain and preserves the signal from proteinaceous fluorophores using a pH-adjusted non-aqueous index-matching med
Despite substantial improvements in the treatment landscape of prostate cancer, the evolution of hormone sensationnel kiyari therapy-resistant and metastatic prostate cancer remains a major cause of cancer-related death globally.The mainstay of treatment for advanced prostate cancer is targeting of androgen receptor signaling, including androgen de
Adaptation in extended populations often occurs through multiple independent mutations responding in parallel to a common selection pressure.As the mutations spread concurrently through the population, they leave behind characteristic patterns of polymorphism near selected loci-so-called soft sweeps-which remain visible after adaptation is complete